Migraine
Conditions
Interventions
S.C. injection of sumatriptan
Sponsors
Erasmus MC
Eligibility
Inclusion criteria
Inclusion criteria: • Age between 18 and 50 years • Male or female • Females should use an oral contraceptive pill • Non-smoking for > 6 months • Body mass index between 18 and 30 kg/m^2 • Capable and willing to give informed consent • General good health, based on medical history and physical examination
Exclusion criteria
Exclusion criteria: • History of cardiovascular disease • Perimenopausal status of females • Any serious illness that can compromise study participation • Use of any medication (e.g., NSAIDs, other analgesics) < 48 hrs before the study • Dermal diseases at the upper frontal side of the face • Pregnancy or breastfeeding • History of sensitivity to the fruits of capsicum plants (e.g. chilli peppers) • Alcohol or drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of change in dermal blood flow response to capsaicin application and saline iontophoresis after sumatriptan or placebo administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Heat sensation after capsaicin application • Blood pressure changes after sumatriptan use | — |
Contacts
Public ContactA.H. Meiracker, van den
Erasmus MC
Outcome results
None listed