Sarcopenia, Pre-operative feeding, Muscle disuse atrophy, Elective hip surgery
Conditions
Interventions
1. This study will be conducted in older patients attending the department of Orthopedics with a scheduled total hip arthroplasty.
2. Subjects are randomized into a feeding and non-feeding group (no
Sponsors
Maastricht University Medical Center (MUMC+), TI Food & Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for total hip arthroplasty; 2. 60-85 years; 3. BMI: 18.5-35 kg/m^2; 4. Functioning gastrointestinal tract, eligible for tube feeding via an intestinal tube.
Exclusion criteria
Exclusion criteria: 1. Co-morbidities and neuromuscular disorders of the lower limbs severely interacting with mobility; 2. Co-morbidities severely interacting with muscle metabolism of the lower limbs; 3. Known renal malfunction (Known renal malfunction without documented approval from nephrologist); 4. Known allergy to milk, milk products and soy; 5. Known galactosaemia; 6. Known gastrointestinal medical history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is muscle and bone protein synthesis expressed as fractional synthesis rates (FSR, %/h). Muscle and bone-protein bound, muscle and bone-tissue free and plasma amino acid enrichments will be measured to calculate precusor and product enrichments. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Total plasma amino acids - Plasma glucose - Plasma insulin - Plasma amino acid enrichments - GI tolerance - Liver, kidney and muscle function | — |
Contacts
Public ContactImre Kouw
Universiteitssingel 50
Outcome results
None listed