MRI of the nerves of the sacral plexus.

Optimization of the MRI protocol for imaging the sacral plexus and its branching nerves.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27087

Enrollment

Registered

2011-02-25

Start date

2011-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anatomy sacral plexus Neurogenic bladder Anatomie sacrale plexus Neurogene blaas

Interventions

Diagnostic MRI images with the following sequences: 1. Diffusion weighted imaging (DWI)

2. Diffusion tensor imaging (DTI)

3. Multi-echo data image combination (MEDIC)

4. Turbo spin echo (TSE) with variable flip angles.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male or female volunteers; 2. Age: 18 years and older; 3. The participant must willingly give written informed consent prior to the start of the study.

Exclusion criteria

Exclusion criteria: 1. Volunteers who underwent surgery in the past related to the lumbosacral spine or pelvis; 2. Volunteers with urologic problems in the past wherefor treated by the (pediatric) urologist; 3. Volunteers with a general contraindication for MRI (including cardiovascular pacemakers, claustrofobia); 4. Volunteers with a BMI (body mass index) of 25 kg/m2. A BMI between 18,5 and 25 kg/m2 is classified as 'normal weight' . BMI is calculated following the equation BMI = mass (kg)/ length^2 (cm); 5. Volunteers who don't want to be informed about incidentally discovered lesions; 6. Employees of the Departments of Pediatric Urology and Radiology of the UMC Utrecht.

Design outcomes

Secondary

Measure	Time frame
The number of non-analyzable images will be registered.	—

Primary

Measure	Time frame
1. Image analysis of the visibility of the nerves of the sacral plexus and the pudendal nerve and pelvic nerve on the MRI images obtained with the different parameter settings following a score system; 2. Analysis of the anatomy of the sacral plexus. The branching of the roots will be assessed; 3. Image analysis of the Contrast to Noise Ratio (CNR) on the different MRI images obtained with the different parameter settings. The mean and SD's of the CNR's will be compared witch each other to assess the image quality; 4. Calculation of the apparent diffusion coefficient (ADC) and the fractional anisotropy (FA) to get insight in the nature of the diffusion. This in view of our follow-up study in children.	—

Measure

Time frame

1. Image analysis of the visibility of the nerves of the sacral plexus and the pudendal nerve and pelvic nerve on the MRI images obtained with the different parameter settings following a score system; 2. Analysis of the anatomy of the sacral plexus. The branching of the roots will be assessed; 3. Image analysis of the Contrast to Noise Ratio (CNR) on the different MRI images obtained with the different parameter settings. The mean and SD's of the CNR's will be compared witch each other to assess the image quality; 4. Calculation of the apparent diffusion coefficient (ADC) and the fractional anisotropy (FA) to get insight in the nature of the diffusion. This in view of our follow-up study in children.

—

Contacts

Public ContactP. Dik

UMC Utrecht Postbus 85090

p.dik@umcutrecht.nl+31 (0)88 7554004

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)