Prediabetes
Conditions
Interventions
The intervention consists of 10 days (2 half days and 8 full days) of passive mild heat acclimation to 35˚
Sponsors
Maastricht University Medical Center+
Eligibility
Inclusion criteria
Inclusion criteria: o Men o Caucasian race o Age 40-70 years o BMI between 25 and 30 kg/m2 o Steady dietary habits o Generally healthy, no medication use that interferes with metabolism. If volunteers need medication (e.g. statin drugs, NSAIDs), it will be reviewed with the dependent physician on individual basis. o Impaired fasting glucose levels between 6.1 and 7.0mmol/L and/or blood glucose values >7.8-11.1mmol/L 2h after sugar drink consumption during OGTT (screening)
Exclusion criteria
Exclusion criteria: o Fasting plasma glucose >7.0 mmol/L o Haemoglobin 3kg in the past three months) o Participation in another biomedical study within 1 month prior to screening visit o Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study o Blood donation three month prior to study and three month after finishing study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oInsulin sensitivity as measured by a 1-step hyperinsulinemic euglycemic clamp oInsulin signalling and heat shock protein expression in muscle tissue | — |
Secondary
| Measure | Time frame |
|---|---|
| o Energy expenditure o Total sweat loss and sweat rate o Body temperatures (core temperature, skin temperature distribution) and skin blood flow o Cardiovascular parameters (blood pressure, heart rate, cardiac output) o Subjective perception of the thermal environment | — |
Contacts
Public ContactWouter Marken Lichtenbelt, van
Universiteitssingel 50, k. 2.312
Outcome results
None listed