Microbiome, MicroRNA, Colorectal cancer, Adenomas
Conditions
Interventions
The patient has to perform two FITs and one stool sample. One extra mucosal biopsy will be taken of found adenomas or CRC only in those patients undergoing a colonoscopy. A questionnaire about dietary
Sponsors
Erasmus Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: - Participants are between 50-75 years old. - Positive FIT in national CRC screening program - Suspicion of CRC - Willing to collect two FIT samples, one stool sample from one stool and fill out one Questionnaire
Exclusion criteria
Exclusion criteria: - Unwilling or not able to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter will be the analysis of the microbiome and miRNA profile in relation to colorectal cancer and adenomas. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To assess the possibility of using the microbiome in a FIT as screening tool for CRC - To assess the possibility of using miRNA panels in a FIT as screening tool for CRC - To assess the difference in diversity and composition of the microbiome in FIT, stool sample and mucosal biopsy - To assess the difference in diversity and composition of miRNA in FIT, stool sample and mucosal biopsy | — |
Contacts
Public ContactM.C.W. Spaander
Erasmus Medical Center Rotterdam
Outcome results
None listed