Prevalence, incidence and adherence of “difficult-to-treat” adult asthma in the Netherlands.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26986

Enrollment

1500

Registered

2012-07-30

Start date

2012-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prevalence adherence difficult-to-treat asthma inhalation technique inhaled corticosteroids Prevalentie therapietrouw astma inhalatietechniek corticosteroiden

Interventions

All patients listed in 73 community pharmacies and using inhaled corticosteroids will be selected, their characteristics will be encoded and translated into a database. This database will be send to t

2. Mixed asthma/COPD (patients with asthma and &#8805

10py)

3. COPD. Patients with COPD will be excluded from further analyses and the prevalence and incidence of difficult-to-treat asthma and the adherence to inhaled therapy will be determined. Additionally

2. Optimal treatment adherence

3. Controlled or uncontrolled asthma.

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients using inhaled corticosteroids for at least 3 months at least one receipt repeated; 2. Patients from study 1 using fluticasone equivalent of ≥1000 µg or ≥ 500µg fluticasone equivalent per day + maintenance of 5mg prednisone per day for at least 30 days; 3. Patients from study 2, who have collected ≥70% of prescriptions in the past 12 months.

Exclusion criteria

Exclusion criteria: COPD.

Design outcomes

Primary

Measure	Time frame
1. The prevalence and incidence of patients with difficult-to-treat asthma in the Netherlands; 2. Factors associated with adherence to pulmonary medication in difficult-to-treat asthma; 3. Primary: Inhalation technique scores in adherent patients with difficult-to-treat asthma; 4. Primary: The proportion of patients with truly severe asthma (i.e. uncontrolled asthma or oral corticosteroid dependent asthma despite good adherence with high dose ICS and adequate inhalation technique).	—

Measure

Time frame

1. The prevalence and incidence of patients with difficult-to-treat asthma in the Netherlands; 2. Factors associated with adherence to pulmonary medication in difficult-to-treat asthma; 3. Primary: Inhalation technique scores in adherent patients with difficult-to-treat asthma; 4. Primary: The proportion of patients with truly severe asthma (i.e. uncontrolled asthma or oral corticosteroid dependent asthma despite good adherence with high dose ICS and adequate inhalation technique).

—

Secondary

Measure	Time frame
1. Primary: Inhalation technique scores in adherent patients with difficult-to-treat asthma; 2. Secondary: Factors associated with adequate or poor inhalation technique; 4. Primary: The proportion of patients with truly severe asthma (i.e. uncontrolled asthma or oral corticosteroid dependent asthma despite good adherence with high dose ICS and adequate inhalation technique); 4. Secondary: Factors associated with controlled or uncontrolled severe, refractory asthma.	—

Measure

Time frame

1. Primary: Inhalation technique scores in adherent patients with difficult-to-treat asthma; 2. Secondary: Factors associated with adequate or poor inhalation technique; 4. Primary: The proportion of patients with truly severe asthma (i.e. uncontrolled asthma or oral corticosteroid dependent asthma despite good adherence with high dose ICS and adequate inhalation technique); 4. Secondary: Factors associated with controlled or uncontrolled severe, refractory asthma.

—

Contacts

Public ContactM. Amelink

m.amelink@amc.uva.nl+31 (0)20 5661660

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)