psychotic disorder medication compliance penfluridol olanzapine risperidone
Conditions
Interventions
comparison of (adherence of) two daily oral antipsychotics (olanzapine and risperidone) to a weekly oral antipsychotic (penfluridol)
Sponsors
Erasmus University Medical Center, Rotterdam
Psychiatry Department
Eligibility
Inclusion criteria
Inclusion criteria: 1. age 18-65 years 2. psychotic disorder, including schizophrenia, schizoaffective disorder, delusional disorder or psychosis not otherwise specified 3. treatment on an outpatient basis or inpatient treatment followed by outpatient care (expected duration of admission less than 6 weeks) 4. psychiatrist treating the patient decides that it is appropriate (based on clinical judgement, guidelines, history and symptoms of the patient) to prescribe either penfluridol, olanzapine or risperidone and that there are no decisive contra-indications 5. patient is willing to use oral neuroleptic treatment, including penfluridol, olanzapine or risperidone 6. able to give informed consent
Exclusion criteria
Exclusion criteria: 1. judicial order stating that taking medication is obliged 2. patient did use penfluridol during the previous six months 3. serious and unstable medical condition 4. insufficient proficiency in Dutch language 5. women who are pregnant 6. patient is on adequate antipsychotic therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time to all-cause medication discontinuation | — |
Secondary
| Measure | Time frame |
|---|---|
| - healthcare related costs - quality of life - reason for treatment discontinuation - efficacy - safety and tolerability - drug attitude - subjective well-being - insight | — |
Contacts
Public ContactC.L. Mulder
Prins Constantijnweg 48-54
Outcome results
None listed