Sarcopenia
Conditions
Interventions
Vegan diet
Sponsors
Wageningen University and research
Eligibility
Inclusion criteria
Inclusion criteria: Aged 65-79 years old; Community-dwelling; BMI 20-35 kg/m2.
Exclusion criteria
Exclusion criteria: - Following a vegetarian or vegan diet during the six months prior to the study; - Following a diet that affects protein intake during the six months prior to the study; - Participating in a structured exercise training program in the past three months; - =5% of body weight loss during three months before the start of the study; - Being diagnosed with one of the following: diabetes; renal disease; neurological or neuromuscular disorders; serious cardiovascular diseases; cancer; chronic obstructive lung disease (COPD); - Chronic use of medication that affects muscle function, e.g. corticosteroids, metformin, insulin; - The use of the following medicines: acenocoumarol (sintrom); phenprocoumon (marcoumar); dabigatran (pradaxa); apixaban (eliquis); rivaroxaban (xarelto); clopidogrel (plavix); combination of acetylsalicylic acid or carbasalate calcium (ascal) with dipyridamole. - Allergic or intolerant to any product included in the diets; - Not willing to stop nutritional supplements, with the exception of supplements on medical advice, and vitamin D; - Not willing or afraid to give blood or undergo a muscle biopsy during the study; - Unwilling to eat a vegan and an omnivorous diet for ten days each; - Not vaccinated for COVID-’19; - Currently a research participant in another trial or participated in a clinical trial during three months before the start of the measurement period; - Not being able to understand Dutch; - Not having a general physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle protein synthesis | — |
Secondary
| Measure | Time frame |
|---|---|
| Satiety; plasma glucose; insulin; plasma lipid profile; blood pressure | — |
Contacts
Public ContactJacintha Domic
Wageningen University
Outcome results
None listed