Anesthesiology
Conditions
Interventions
After induction of anaesthesia and once a steady state haemodynamic phase has been reached before incision, all patients will be administered 5ml kg-1 crystalloids i.v. in 5-10 minutes. The haemodynam
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: • Patients scheduled for elective non-cardiac surgery requiring invasive arterial blood pressure monitoring. • Patients older than 18. • ASA physical status I-III. • Informed and willing to give written informed consent.
Exclusion criteria
Exclusion criteria: • Patients who refuse to participate. • Patients unable to consent (i.e. severe mental disorder, younger than 18). • Patients with pacemakers. • Patients with severe cardiac pathologies or hemodynamically unstable. • Patients with end-stage renal failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is the agreement of COqCO with reference CO in terms of bias, precision and trending ability. The change in RPVI will be assessed with respect to changes in SVV, to evaluate the ability of RPVI to track fluid-induced changes in preload dependency. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Analysis of the variability of qCO derived CO during the different hypnotic conditions of the patient (awake, anaesthetic induction phase, steady state general anaesthesia). - Comparison of the prediction of fluid responsiveness by RPVI with both FloTrac/EV1000-derived SVV and traditional PVI. - Ability of RPVI to predict fluid responsiveness, defined as an increase in CO > 15%, and comparing it with the ability of SVV to predict fluid responsiveness. | — |
Contacts
Public ContactR. Spanjersberg
Hanzeplein 1
Outcome results
None listed