drug-drug interaction chronic renal failure depression neuropathic pain
Conditions
Interventions
Intake of amitriptyline alone and amitriptyline with polysytrene sulfonate
Sponsors
Deventer Ziekenhuis
Eligibility
Inclusion criteria
Inclusion criteria: - The participant is at least 18 years of age
Exclusion criteria
Exclusion criteria: - Known allergy to one of the investigated substances - Known renal or hepatic impairment - Pregnancy - Breast feeding - Use of other medication within 24 hours of the study period (oral contraceptives within 12 hours of the study period) - Contra-indication for one of the investigated substances (such as recent myocardial infarction, cardiac arrhythmias, hypokalaemia and obstructive bowl disease) - History of a gastro-intestinal condition that may interfere with absorption of amitriptyline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether polystyrene sulfonate has an effect on exposure of amitriptyline, when taken simultaneously, compared to amitriptyline taken alone in healthy volunteers, expressed in Cmax and AUC0-8h. | — |
Contacts
Public ContactIlona Prins-Can
Deventer ziekenhuis
Outcome results
None listed