Metabolic effects of deep brain stimulation in patients with obsessive compulsive disorder.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26928

Enrollment

Registered

2009-09-10

Start date

2009-01-10

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Hyperinsulinemic euglycemic clamp with stable isotopes.

Eligibility

Inclusion criteria

Inclusion criteria: Patients with OCD with deep brain stimulation in the nucleus accumbens.

Exclusion criteria

Exclusion criteria: 1. Use of psychotropic drugs; 2. Use of drugs or abuse; 3. Pregnancy; 4. Use of medication known to interfere with glucose or lipid metabolism; 5. DMII or impaired fasting glucose; 6. Primary lipid disorder; 7. Performance of vigorous exercise; 8. Renal insufficiency or elevated liver enzymes.

Design outcomes

Primary

Measure	Time frame
1. HPS axis activity; 2. Endogenous glucose production.	—

Secondary

Measure	Time frame
1. Lipid metabolism; 2. Resting energy expenditure.	—

Contacts

Public ContactN.M. Lammers

Academic Medical Centre (AMC) Department of Endocrinology & Metabolism F5-162

N.M.Lammers@amc.uva.nl+31 (0)20 5662663

Outcome results