SIRS and sepsis and critical illness related organ failure
Conditions
Interventions
None listed
Sponsors
Academic Medical Center, Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: Intubation and mechanically ventilation and an expected ICU-stay > 24 hours.
Exclusion criteria
Exclusion criteria: 1. Age < 18 years; 2. Expected pregnancy. The following patients will be measured but are excluded from primary analyses: 3. Known chronic pulmonary condition, detectable by electronic nose (asthma, pulmonary malignancy, tuberculosis, cystic fibrosis); 4. Admitted to another ICU in the last 7 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Breathprints obtained by electronic nose (Cyranose and ContiNose); 2. Specific VOCs detected by GC-MS. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Sepsis and probability of infection; 2. Organ failure; 3. Systemic biomarkers of inflammation, coagulation, organ failure, etc; 4. Pulmonary biomarkers of inflammation, coagulation, etc; 5. Pulmonary microbiome. Other: General demographical, clinical and physiological data are collected for calculation of acute physiology, age and chronic health (APACHE) II and III scores, simplified acute physiology scores (SAPS) II, and sequential organ failure assessment (SOFA) scores. Daily laboratory include WBC & differentials, platelet counts, creatinine, ASAT, ALAT, glucose, PT, aPTT, and lactate. Infections on admission and during stay on the ICU are recorded. Outcome data include duration of mechanical ventilation, length of stay in ICU and hospital, and 30–day -, 90–day - and 1–year mortality. | — |
Contacts
Public ContactLieuwe D.J. Bos
Academic Medical Center, Room G3-228 Meibergdreef 9
Outcome results
None listed