Prokinetics to alter the position of the gastric acid pocket in Gastro Esophageal Reflux Disease.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26838

Enrollment

Registered

2009-08-28

Start date

2009-01-09

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastro esophageal reflux disease GERD heartburn, zuurbranden.

Interventions

Administration of azitromycin.

Eligibility

Inclusion criteria

Inclusion criteria: GERD patients with a hiatal hernia: 1. 18-65 years; 2. Esophagitis and/or pH-metry with an acid exposure of > 4,5%; 3. Hiatal hernia as seen on endoscopy or barium swallow of > 3 cm. GERD patients without a hiatal hernia: 1. 18-65 years; 2. Esophagitis and/or pH-metry with an acid exposure of > 4,5%; 3. No hiatal hernia or a hiatal hernia < 2 cm as seen on endoscopy or barium swallow.

Exclusion criteria

Exclusion criteria: 1. Surgery of the gastrointestinal tract other then appendectomy; 2. Use of medication that interfere with gastrointestinal motility; 3. Inability to stop the use of proton pump inhibitors twice for one week; 4. Participation in another study with exposure to radiation within the last year.

Design outcomes

Primary

Measure	Time frame
The rate of acid reflux episodes.	—

Secondary

Measure	Time frame
1. The rate of acid versus non acid reflux events; 2. The position of the acid pocket, relative to the lower esophageal sphincter and crural diaphragm; 3. The rate of TLESRs; 4. Gastric emptying.	—

Contacts

Public ContactG.E.E. Boeckxstaens

Academic Medical Center (AMC), Department of Gastroenterology, C2-328, P.O. Box 22660

g.e.boeckxstaens@amc.uva.nl+31 (0)20 5667375

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)