Cesarean section, keizersnede Vaginal delivery, vaginale partus Intestinal colonization, intestinal kolonisatie Microbiota, microbioom Antibiotics, antibiotica
Conditions
Interventions
- 20 women will be treated according the current protocol on antibiotic administration (antibiotic administration after clampsing of the umbilical cord)
- 20 women will be treated according to the NVOG protocol (administration of antibiotics just prior to skin incision)
- 20 women admitted for outpatient vaginal delivery will be asked to participate
Sponsors
VU medical center
Eligibility
Inclusion criteria
Inclusion criteria: Mother: - Delivery at a gestational age > 36+6 weeks - Vaginal or primary cesarean delivery - Written informed consent
Exclusion criteria
Exclusion criteria: Mother: - Age 30 - Inflammatory bowel diseases, celiac disease - Major gastro-intestinal operation in the past (e.g. bowel resection, gastric bypass) - Diabetes mellitus type1 and 2, and gestational diabetes mellitus insuline dependent) - intoxications (smoking, alcohol or drugs) Exclusion after delivery Mother - Antibiotic use during first month Neonate - Antibiotic use during first month - Usage of immunosuppresive drugs during first month - Congenital gastro-intestinal disease - Gastro-intestinal operation during first month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ƒ{1. To describe and compare intestinal microbiome colonisation (by means of IS-pro) of neonates born by cesarean section, in terms of timimng of antibiotics treatment: prior to caesarean section (NVOG protocol) or after clamping of the umbilical cord (currently used protocol). | — |
Secondary
| Measure | Time frame |
|---|---|
| ƒ{-To describe and compare intestinal microbiome colonisation of vaginally delivered neonates with those born by caesarean section by means of IS-pro analysis. - To evaluate effects of maternal vaginal and rectal microbiota composition on neonatal gut microbiota colonisation. | — |
Contacts
Public ContactJ.I.P. Vries, de
VU Medical Center, Department of Obstetrics and Gynaecology, P.O. Box 7057
Outcome results
None listed