Obesity
Conditions
Interventions
This study consists of two interventions involving one calcitriol and one placebo (saline) infusion (order determined upon randomization).
Sponsors
Investigator initiated trial
Eligibility
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: ? Age between 18 – 35 years; ? Capability to provide informed consent; ? Stable weight (74 pmol/l at screening (89).
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: ? ? Any medical disorder (with the exception of metabolic syndrome and other obesity-related disorders in the obese subset); ? Childhood-onset obesity; ? Contraindication to MRI scanning (e.g. claustrophobia, pacemaker, metal IUD); ? Participants who skip their breakfast or work in shifts; ? Serum 25-hydroxyvitamin D (25(OH)D) concentrations below 50 nmol L-1; ? Significant sensory or motor impairment; ? Subjects taking any medication except for medication for obesity-related metabolic disorders (excluding diabetes treatment) ? Subjects who cannot adhere to the experimental protocol for any reason; ? The use of weight loss agents or use within 3 months prior to study; ? Weight loss surgery or gastrectomy. ? Hypercalciemia at screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effects of calcitriol on neuronal activity in brain areas involved in food intake using functional magnetic resonance imaging (fMRI) in lean and obese subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| The differences in calcitriol-induced dopaminergic effects between lean and obese participants and the effects of calcitriol on satiety, energy metabolism, and food-related behavior (questionnaires) in association with changes in fMRI responses. | — |
Contacts
Public ContactSabrina Oussaada
Amsterdam UMC
Outcome results
None listed