Neurocognitive mechanisms of relapse prevention in depression, a fMRI-study

Predicting and Understanding Neurocognitive Mechanisms of Relapse Prevention: a randomized controlled trial of preventive cognitive therapy in remitted Major Depressive Disorder using fMRI and pupillometry

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26793

Enrollment

100

Registered

2015-08-19

Start date

2015-08-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Prevention,Relapse, fMRI Depressie, preventie, terugval, fMRI

Interventions

Protocolised Preventive Cognitive Therapy

Eligibility

Inclusion criteria

Inclusion criteria: between 18 - 60 years of age current remission (>2 months; according to criteria in DSM IV) >2 major depressive episodesin past 5 years recency of last episode 4 weeks)

Exclusion criteria

Exclusion criteria: current major depressive episode current use of anti-depressant medication neurological problems drug abuse use of psychotropic medication other than frequent use of benzodiazepine anu other current DSM IV Axis-I diagnosis, as objectified with the SCID-I MRI contra indications

Design outcomes

Primary

Measure	Time frame
Testing whether preventive cognitive therapy in remitted patients results in increased prefrontal control and whether this increased prefrontal control results in a decrease in attentional biases and increase in emotion regulation capacity.	—

Secondary

Measure	Time frame
Predict individual treatment succes in remitted depressed patients based on neurocognitive measures. Translate neurocognitive principles to clinically usefull measures to predict and monitor individual preventive cognitive therapy success.	—

Contacts

Public ContactM.J. van Tol

Cognitive Neuroscience Center, University Medical Center Groningen

m.j.van.tol@umcg.nl050 3616405

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)