Type 2 diabetes mellitus, NASH, dyslipidemia Diabetes mellitus type 2
Conditions
Interventions
1. Liverbiopsy
2. Bloodwithdrawal.
Sponsors
Academic Medical Centre Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: Patients with DM: 1. Caucasian males or females; 2. Age 18 - 60 years old; 3. Type 2 diabetes mellitus; 4. Presence of ultrasound confirmed NASH; 5. Undergoing gastric bypass surgery. Controls: 1. Caucasian males or females; 2. Age 18 - 60 years old; 3. FHBL patients with NASH and Hepatitis C patients and Heamochromatosis patients undergoing a liverbiopsy for clinical staging of the disease and patients undergoing hemihepatectomy.
Exclusion criteria
Exclusion criteria: 1. Use of lipid lowering therapy (Modalim), hormone therapy or other medication which influences the lipid metabolism during the past 6 weeks; 2. Active malignancy (not applicable to hemihepatectomy patients); 3. Cholestasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HSPGs expression in liver tissue, measured by qPCR and western blot, in insulin resistant NASH versus non-insulin resistant NASH and controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Association between hepatic HSPGs expression en triglyceride-rich lipoproteins in non-fasting lipid samples; 2. Association between hepatic HSPGs expression and HOMA index. | — |
Contacts
Public ContactH.C. Hassing
Meibergdreef 9
Outcome results
None listed