stroke
Conditions
Interventions
The intervention consists of the administration of a single dose of 20 mg fluoxetine on one day and the administration of placebo on the other day to all participants.
Sponsors
Roessingh Research & Development
Eligibility
Inclusion criteria
Inclusion criteria: 1. First ever ischemic stroke, confirmed with a CT-scan or MRI-scan 2. Unilateral cortical and/or subcortical stroke 3. Stroke more than 6 months ago 4. Some motor dysfunction of the arm/hand but some motor function left (MRC between 2 and 4) 5. Age between 18 and 80 years 6. Obtained informed consent
Exclusion criteria
Exclusion criteria: 1. Other (pre-existing) neurological diseases (e.g. epilepsy, tumor, paralysis) 2. Known allergy to SSRI’s 3. Use of anti-depressants (tricyclic antidepressants, serotonin reuptake inhibitors, MAO-inhibitors) 4. Autism spectrum disorders, PDD, schizophrenia (or history of schizophrenia) 5. Unstable medical health situation (cardiovascular and/or neurological) 6. Uncompensated hemineglect or cognitive disabilities, resulting in misunderstanding or incapability of executing instructions given 7. Uncorrected visual problems, i.e. not able to observe the movie on the screen 8. Pregnancy 9. Breastfeeding 10. Known kidney dysfunctions 11. Severe uncontrolled medical conditions 12. Known alcoholism or drug abuse 13. Known elevated brain pressure (hydrocephalus)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - EEG after fluoxetine intake and during movement observation | — |
Secondary
| Measure | Time frame |
|---|---|
| - Fugl-Meyer motor assessment, EMG, force production | — |
Contacts
Public ContactH.I. Genderen, van
Roessingh Research and Development Rehabilitation Centre P.O. Box 310
Outcome results
None listed