Epilepsy
Conditions
Interventions
This study is a non-interventional study
Sponsors
Maastricht University Medical Center+
Eligibility
Inclusion criteria
Inclusion criteria: • Medically refractory epilepsy • No possibility for resective epilepsy surgery • Incapacitating epilepsy or seizures • Pattern of seizures has to be fit for appropriate assessment • Minimum age 18 years • Patient or caregiver must be able to register seizures in some way
Exclusion criteria
Exclusion criteria: • Underlying malignancies, whenever life expectancy is lower than 2 years • Co-medication with anti-inflammatory drugs or systemic diseases with inflammation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We use clinical response to the treatment as a primary endpoint. We will distinguish two groups: Patients with a poor response and patients with a good to excellent response. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The degree of electrophysiological connectivity between the ATN and the cerebral cortex as measured directly in the phase postoperatively (single measurement) 2. The profile (increase/decrease) of inflammation parameters in peripheral blood over the 2 years after start of the treatment (thus over 4 blood samples in 2 years) | — |
Contacts
Public ContactR. Rouhl
PO Box 5800
Outcome results
None listed