The origin of pain in the Subacromial Pain Syndrome.

Central pain sensitisation or (peri)articular damage: the origin of pain in SAPS. A randomised, placebo controlled, blinded, cross-over trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26751

Enrollment

Registered

2017-05-12

Start date

2017-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subacromial Pain Syndrome

Interventions

In a randomised sequence, participants will receive two US guided subacromial injections: one with anaesthetics (5cc lidocaine 1%, using a 50 mm 21 gauge needle) and one with a placebo (5cc NaCl 0.90%

Eligibility

Inclusion criteria

Inclusion criteria: - Chronic shoulder pain (>3 months) - Unilateral shoulder pain - Suspicion of subacromial origin of pain (e.g. positive painful arc test, Hawkins-Kennedy test, empty can test) - Presence of conventional ultrasonography - Presence of conventional radiographs

Exclusion criteria

Exclusion criteria: - Younger than 18 years of age - Tendinitis calcarea - Full thickness rotator cuff tear - Suspicion of capsulitis adhesiva after clinical examination - Glenohumeral osteoarthritis - Medication that potentially act on central pain sensitisation (e.g. pregabalin, amitriptylin, duloxetine) - Use of opioid analgesics, e.g. oxycodone. - Suspicion of symptomatic acromioclavicular osteoarthritis (e.g. positive cross body adduction test) - History of fractures or dislocations of the shoulder - Cardiac disease - Comorbidities: neurological disorders (e.g. plexus lesion), rheumatic disorders (e.g. polymyalgia rheumatic), muscle dystrophies, metabolic disorders (e.g. hypothyreodism), neoplasms - Diagnosed with other chronic pain syndrome, e.g. diabetic polyneuropathy, chronic low back pain or fibromyalgia - Insufficient Dutch language skills - No informed consent

Design outcomes

Primary

Measure	Time frame
1) (peri)articular pain determined from effect of subacromial injections on pain at rest and during abduction assessed with a visual analogue scale (VAS), 2) pain sensitisation assessed with bilateral Quantitative Sensory Testing (QST), 3) shoulder muscle activation (expressed as Activation Ratios, ARs).	—

Secondary

Measure	Time frame
Secondary study parameters (determinants) are two anchor questions for pain, findings from ultrasonography, questionnaires and demographics.	—

Contacts

Public ContactC.L. Overbeek

c.l.overbeek@lumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)