Chronic wounds (> 3 weeks)
Conditions
Interventions
There are no interventions because this is a diagnostic study.
Sponsors
University of Graz, Austria
Eligibility
Inclusion criteria
Inclusion criteria: 1. Open chronic wound (>3 weeks); this will be mainly: A. Diabetic foot ulcer; B. Ulcus cruris (arterial or venous); C. Decubitus ulcer; D. Operation wounds, healed by secundary intention or wound dehiscention. 2. ≥ 18 years of age; 3. Patients from the department of Surgery or Dermatology.
Exclusion criteria
Exclusion criteria: 1. Use of antibiotics in the last five days; 2. Malignant wounds; 3. Fully necrotic wounds; 4. Fully dry wounds; no production of wound fluid in last 2 days; 5. Allergy or hypersensitivity for Lidocaine, when local anaesthesia is necessary; 6. Wounds that are completely covered with exposed periosteum; 7. Wounds with a diameter < 2 millimeters; 8. Facial wounds; 9. Haematological disorders with risk of uncontrolled bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity, specificity, positive and negative predictive value and the AUC of the enzyme analyses with wound biopsies as gold standard are the main study parameters. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the clinical relevance of the enzyme analyses, the diagnostic properties of both wound swab and clinical judgment, when compared to wound biopsies, will be calculated. Furthermore, the enzyme analyses should point out what enzymes are present in the wound fluid. The types of bacteria that causes the infection is identified from wound biopsy. | — |
Contacts
Public ContactJ. Palen, van der
Medisch Spectrum Twente, P.O. Box 50000
Outcome results
None listed