Colorectal cancer
Conditions
Interventions
1-sample or 2-samples immunochemical FOBTs.
Firstly, a representative population sample of 2.500 asymptomatic persons between
50-75 years of age in the region ‘Rijnmond’ will be invited for the 1st
Sponsors
Erasmus Medical Center, Rotterdam
Department of Gastroenterology and Hepatology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Asymptomatic individuals aged 50-75 years old, who are able to provide an informed consent.
Exclusion criteria
Exclusion criteria: 1. Inability or refusal to provide informed consent 2. History of CRC or inflammatory bowel disease 3. Severe or terminal disease, life expectancy less than 5 years 4. Colonoscopy, sigmoidoscopy or contrast barium enema within the previous three years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adherence for second round CRC screening with 1-sample iFOBT (OC-Hemodia Latex) comparing annual, biennial, and triennial screening interval. Adherence and diagnostic yield of a first screening round comparing 1-sample versus 2-sample iFOBT screening. | — |
Secondary
| Measure | Time frame |
|---|---|
| The diagnostic yield of the various intervals of a second round iFOBT screening. The feasibility and required colonoscopy capacity needed for further evaluation of participants with a positive iFOBT screening. Side effects of screening. Participants’ experiences; the acceptability, satisfaction and burden of screening in different rounds and use of one or two-sample iFOBT. Reasons for non-participation. The cost-effectiveness ratio of the three different screenings-intervals and the one and two-sample iFOBT. | — |
Contacts
Public ContactA.H.C. Roon, van
Erasmus MC, University Medical Center Rotterdam Department of Gastroenterology and Hepatology
Outcome results
None listed