frequent premature ventricular contractions frequent ventricular ectopic beats left ventricular dysfunction anti-arrhythmic drugs children frequente premature ventriculaire contracties frequente overslagen van de hartkamers linker kamer dysfunctie anti-aritmica kinderen
Conditions
Interventions
In a pediatric cohort of patients the acute effect of beta-blocker vs flecainide on the amount of PVCs will be tested in an open label cross-over design. After baseline function testing patients will
Sponsors
Leiden University Medical Center
Leiden, the Netherlands
Eligibility
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: - Age ¡Ý 1 year and 15% on two different 24-hour Holter recording - With or without asymptomatic VT
Exclusion criteria
Exclusion criteria: - Age < 1 year, because of the significant chance of spontaneous resolution of PVCs - Structural cardiac defects - History of cardiac surgery - Myocarditis - Cardiomyopathies - Long QT-syndrome - Catecholaminergic Polymorfic Ventricular Tachycardia (CPVT) - Verapamil sensitive PVC / Ventricular Tachycardia (VT) - Patients with mental retardation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The acute effect of flecainide and metoprolol on the reduction of PVCs as measured on Holter registration. | — |
Secondary
| Measure | Time frame |
|---|---|
| The function of the left and right ventricle as measured by echocardiography and cardiac magneticresonance imaging, and NT-pro-BNP levels in the blood. | — |
Contacts
Public ContactR.A. Bertels
Outcome results
None listed