prosocial behavior, oxytocin, 5-HT1a receptor, MDMA
Conditions
Interventions
Administration of treatments* and collection of a blood sample each test day to determine treament concentrations and oxytocin concentrations in the blood.
*There are 4 treatment conditions and these
2. Syntocinon (32 international units)
3. MDMA (75 mg) combined with Visken (20 mg)
4. Placebo.
Sponsors
Dr. Kim Kuypers,
Dept. of NP & PP, Fac of FPN, UM
P.O.Box 616
6200 MD Maastricht
tel: +31433881902
fax: +31433884560
email: k.kuypers@maastrichtuniversity.nl
Eligibility
Inclusion criteria
Inclusion criteria: 1. Experience with the use of MDMA (maximally 100 times in total, minimally 2 times in total; and at least once in the past 12 months); 2. Age between 18-40 years; 3. Free from medication (except oral contraception); 4. Good physical health as determined by examination and laboratory analysis; 5. Absence of any major medical, endocrine and neurological condition; 6. Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2; 7. Written Informed Consent; 8. Native Dutch speaker (as some tasks require this).
Exclusion criteria
Exclusion criteria: 1. History of drug abuse (other than the use of MDMA) or addiction; 2. Women: Pregnancy or lactation; 3. Cardiovascular abnormalities as assessed by standard 12-lead ECG; 4. Excessive drinking (> 20 alcoholic consumptions a week); 5. Hypertension (diastolic> 100; systolic> 170); 6. Current or history of psychiatric disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Dependent variables of the empathy and social interaction tasks, measured with computertasks; 2. Treatment concentrations and oxytocin concentrations in the blood (bloodsample). | — |
Secondary
| Measure | Time frame |
|---|---|
| Dependent variables of the control task: Word learning task. | — |
Contacts
Public ContactK.P.C. Kuypers
P.O. Box 616
Outcome results
None listed