breast implant illness
Conditions
Interventions
None listed
Sponsors
Maastricht umc
Eligibility
Inclusion criteria
Inclusion criteria: • Age: 25 to 76 years old • Diagnosis of ASIA-syndrome vs. no complaints • No diagnosis of a chronic pain syndrome, fibromyalgia (FM) or chronic fatigue syndrome (CFS). • Silicone filled breast implants • Cosmetic purpose of silicone breast implants • Cognitive impairment and/or memory disturbances1 • Competent patients
Exclusion criteria
Exclusion criteria: • Cancer • Diabetes Mellitus • Claustrophobia or fear of being in a closed space • Neuropathy of the upper or lower extremities • Medication2: antidepressants, any analgesics, anticonvulsants, muscle relaxants or benzodiazepines • MRI incompatible health condition (i.e., ICD, pacemaker or other metal prosthetic implants) • History of CVA/TIA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Structural MRI (including gray matter volume) Resting-state fMRI (rs-fMRI) ? intrinsic connectivity of the brain in the resting basal state Diffusion Tensor Imaging (DTI) ? Fractional anisotropy (FA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline characteristics: age, BMI, education, occupation, duration of silicone exposure Pain severity, measured with the Chronic Pain Grade. Cognitive impairment, measured with MMSE | — |
Contacts
Public ContactRenée Miseré
MUMC
Outcome results
None listed