Onderzoek naar nieuwe diagnostische markers voor vroeg-diagnostiek van necrotiserende enterocolitis bij pasgeborenen.

Novel diagnostic markers for necrotizing enterocolitis in the premature infant.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26582

Enrollment

Registered

2012-01-16

Start date

2010-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotizing enterocolitis (NL: necrotiserende enterocolitis)

Interventions

When patient is suspected of NEC: 1. Collecting of blood and urine samples at 10 subsequent intervals

2. Measuring cerebral and abdominal tissue oxygenation by near infrared spectroscopy (NIRS)

3. When patients are being operated on: Measuring bowel oxygenation by visible ligth spectroscopy (VLS).

Eligibility

Inclusion criteria

Inclusion criteria: Patients in the neonatal intensive care unit with (suspected) NEC (Bell's stage 1 or higher).

Exclusion criteria

Exclusion criteria: 1. Congenital bowel defects; 2. Intensive light therapy for hyperbilirubinaemia necessitating the use for three phototherapy lamps.

Design outcomes

Primary

Measure	Time frame
1. Urinary I-FABP/claudine to creatinine ratio; 2. Tissue oxygenation as measured by NIRS.	—

Secondary

Measure	Time frame
Inflammatory/metabolic markers (such as WBC, CRP, TNFa, pH value, lactate and interleukines).	—

Contacts

Public ContactM. Schurink

UMC Groningen Hanzeplein 1

m.schurink@umcg.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)