pain processing endogenous pain modulation sedation verwerken van pijnprikkels endogene pijnstilling sedatie
Conditions
Interventions
We will perform fMRI scans and experimental pain tests prior to and after spinal anesthesia at the level of L4/5.
Sponsors
LUMC
Eligibility
Inclusion criteria
Inclusion criteria: Healthy male volunteers, aged 18 to 45 years, right-handed
Exclusion criteria
Exclusion criteria: - Obesity (BMI > 30); - Significant history of any cardiac or vascular disorder, asthma or other pulmonary disease, major gastrointestinal abnormalities, peptic ulceration, hepatic, neurological, psychiatric, hematological (including bleeding disorders), endocrine, renal, or major genitourinary disease; - History of illness, condition or medication use that, in the opinion of the investigator, might interfere with optimal participation, confound the results of the study or pose additional risk in administering spinal anesthesia to the subject; - History of chronic alcohol or illicit drug use; - Metal medical devices like pacemakers, knee or hip prosthesis, ear implants, vessel clips, subcutaneous insulin pumps or carries metal particles (e.g. metal splinter in the eye) inside the body; - Claustrophobia; - Allergy to study medications; - Not able to maintain a regular diurnal rhythm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI analysis, BOLD response. | — |
Secondary
| Measure | Time frame |
|---|---|
| experimental heat pain, performed with the Pathway (Medoc Ltd, Ramat Yishai, Israel), a device that is able to heat a probe to a predefined temperature. | — |
Contacts
Public ContactL.C.J. Oudejans
Afdeling anesthesiologie P5-46 Albinusdreef 2
Outcome results
None listed