dementia
Conditions
Interventions
none
Sponsors
none
Eligibility
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: Patients who attended the memory clinic of the Leiden University Medical Center/ Bronovo hospital within one year ago • Diagnosed with probable AD • Diagnosed as MCI • Diagnosed as SCI • Diagnosed as VaD • Capable of giving informed consent (see appendix) Control subjects • Healthy adults without memory complaints aged between 40-90 years old
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Contra-indication to MRI scanning: • Claustrophobia • Pacemakers and defibrillators • Nerve stimulators • Intracranial clips • Intraorbital or intraocular metallic fragments • Cochlear implants • Ferromagnetic implants • Hydrocephaluspump • Intra-utrine device (not all types) Permanent make-up • Tattoos above the shoulders (not all) - Specific contraindications to fMRI • Seizure within prior year. • Noncorrectable visual impairment. - MMSE < 19 points (measured at moment of screening or at memory clinic with a maximum of 6 months in retrospect) (this cutoff was also used in the Leiden 85-Plus study30) - Severe physical restrictions (completely wheelchair dependent) - Age above 90
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in BOLD signal in response to visual stimulation including the amplitude of the BOLD response in percentage signal change between stimulus on and off, time-to-peak response (sec), and time-to-baseline (sec) after discontinuation of the visual stimulus will be analyzed.4, 5 Only normal appearing tissue will be taken for analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Classic signs of CAA will be determined according to the Boston criteria26: intracranial hemorrhage, lobar microbleeds, subarachnoidal hemorrhage and superficial siderosis will be scored as previously described.31 Also other cerebral SVD markers will be scored: number of small subcortical infarcts and lacunes32, volume of WMHs33, perivascular spaces in the basal ganglia and centrum semiovale34, number and location of microbleeds35 and grey matter volume using Sienax.36 | — |
Contacts
Public ContactSanneke van Rooden
LUMC
Outcome results
None listed