Skip to content

The effect of nebulised salbutamol and isotonic saline on exercise induced bronchoconsonstriction in elite skaters following a 1500 meter race.

The effect of nebulised salbutamol and isotonic saline on exercise induced bronchoconsonstriction in elite skaters following a 1500 meter race.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON26511
Enrollment
41
Registered
2012-07-31
Start date
2012-10-11
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elite skaters perform in cold air, an environment which has a low absolute humidity. In training and during competition, when the level of exertion is high, the skater repeatedly breathes cold and dry air, resulting in an inflammation of the lungs similar to that seen in asthma. This inflammation may cause bronchus obstruction after exercise. In order to combat the consequences of performing in dry or unconditioned air, this research makes use of a fully portable ultrasonic nebulizer (OMRON).

Interventions

Nebulization with 1 mg Salbutamol by means of ultrasonic nebulization after speedskating a distance of 1500 metres. Placebo group nebulization with 0.9% sodium chloride (NaCl). The control group will

Sponsors

drs. J.M.M. Driessen Thialfweg 41 8441 PW Heerenveen
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 35 years; 2. Elite speedskater; 3. Women: 1500 meter time below 2:10:00 minutes; 4. Men: 1500 meter time below 02:05:00 minutes. These times should have been skated within a period of two months prior to study measurement; 5. Able to undergo reproducible lung function tests. Three-fold repetition of FEV1 measurements, with a mutual difference of maximal 5 percent (Miller, et al, 2005).

Exclusion criteria

Exclusion criteria: 1. Ultrasonic nebulization with tap water or saline solutions within 48 hours before testing; 2. FEV1 <70%; 3. Respiratory infection within 6 weeks prior to examination for which medication should be prescribed; 4. Use of short acting beta agonists 8 hours before exercise; 5. Use of long acting beta agonists 24 hours before exercise; 6. Use of a leukotriene-receptor-antagonist 36 hours before exercise.

Design outcomes

Primary

MeasureTime frame
The effect on the decrease in FEV1 after exercise by ultrasonic nebulization with salbutamol 1 mg or 0.9% sodium chloride (NaCl) (Carlson, et al, 2008, Carlson, et al, 2008) compared to controls with no intervention.

Secondary

MeasureTime frame
1. Analyze the change in airway resistance after exercise, measured with the FOT and the effect of salbutamol on this change compared to, 0.9% NaCl and controls; 2. Analyzing the change in respiratory reactance after exercise, measured with the FOT and the effect of salbutamol on this change compared to 0.9% NaCl and controls; 3. Analyzing the change in electro physiological activity of the respiratory muscle system, measured with EMG with salbutamol on this change compared to , 0.9% NaCl and controls.

Contacts

Public ContactMargryt Gerritsma

Jan Jonkmanweg 1

m.gerritsma@st.hanze.nl+31 (0)6 28760059

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)