Breast cancer
Conditions
Interventions
No interventions.
Measurements:
Patients who come to the centre for mammacare with a suspicious breast lesion and who follow the inclusion criteria of the current phase, will be asked for cooperatio
Sponsors
Prof. dr. ir. Wiendelt Steenbergen
On behalf of Biomedical Photonic Imaging, University of Twente
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult women, who come to the Centre for Mammacare with a lesion suspicious for malignancy that, after clinical investigation and anamnesis is classified as a BIRADS IV or V (Phase 1,2) or a BIRADS I or II (phase 3) lesion. In addition, the lesion or suspect must have been deemed as being manifestable in a photoacoustic examination; 2. Patients in good general health that allows them to undergo the examination in a prone position for a period of 45 minutes; 3. Patients who are fully competent to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients whose physical condition is expected to be insufficient for mounting the examination bed and staying on this bed for 45 minutes without too much discomfort; 2. Patients who had a breast biopsy in 3 months prior to this study; 3. Patients with bloody discharge, ulcers or wounds on the breast; 4. Patients with a history of surgery (including cosmetic surgery) or radiation therapy on the breast within a period of 5 years prior to the study; 5. Patients with breast implants; 6. Patients who currently undergo chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Photoacoustic images will be compared with the outcomes of clinical investigation, conventional imaging and pathology. In the first stage of the study, the photoacoustic images will mainly be used to optimize the measurement and analysis methods. In the second phase of the study, the images of the BIRADS IV and V lesions will qualitatively be described in order to find photoacoustic markers that are indicative for malignancy. In the third stage of the study, which will have a certain overlap with phase 2, also non-cancerous breast will be investigated for the presence or absence of the photoacoustic malignancy markers. | — |
Contacts
Public ContactM. Heijblom
MIRA Institute for Biomedical Technology and Technical Medicine University of Twente P.O. Box 217
Outcome results
None listed