Twin Anemia Polycythemia Sequence (Tweeling Anemie Polycythemie Sequentie) Monochorionic Twins (Monochoriale tweelingen) Feto-fetal transfusion syndrome (foeto-foetaal transfusiesyndroom) Fetoscopic Laser Surgery (Foetoscopische Laserchirurgie) Twin-to-Twin Transfusion Syndrome (Tweelingtransfusiesyndroom)
Conditions
Interventions
In the experimental group fetoscopic laser surgery is performed, whereas the control group is treated with standard care (expectant management, IUT (with PET), selective feticide and/or preterm delive
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: • Monochorionic twin pregnancy complicated by either spontaneous or post-laser TAPS, stage ≥ 2, diagnosed between 20+0 and till 28+0 weeks of gestation • Women aged 18 years or more, who are able to consent.
Exclusion criteria
Exclusion criteria: • TAPS stage 1 • TAPS stage≥ 2, diagnosed within 1 week after laser surgery for TTTS* • Triplet pregnancies, or higher order multiple pregnancies • TAPS cases that already underwent an intrauterine treatment (with the exception of laser surgery for TTTS in post-laser TAPS cases) • Congenital abnormalities (including severe cerebral injury) in one or both twins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is gestational age at birth. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include: perinatal mortality or severe neonatal morbidity, hematological complication, procedure related complications and long-term neurodevelopmental outcome at 2 years. | — |
Contacts
Public ContactL.S.A. Tollenaar
Leiden University Medical Center, Building 1, Room J-06-182
Outcome results
None listed