Abdominal aneurysm, Aortic surgery, Ischemia Reperfusion Injury, Enteral nutrition, Metabolic route, Glutamine, Citrulline, Arginine, alanyl-glutamine, Kidney
Conditions
Interventions
Group A and B: 5 patients will receive a primed continuous infusion of 0.5 g/kg/24hr L-alanyl-L-glutamine intravenously, starting 12 hours before surgery.
Group C (control group): Patients do not rec
Sponsors
VU University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing aortic replacement surgery for abdominal aneurysm; 2. Age: > 35 and < 70 years; 3. BMI < 35; 4. Having obtained his/her informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients not fit for surgery as decided by the anesthesiology department (renal/hepatic insufficiency or heart failure); 2. Hepatitis, severe cirrhosis, urea cycle disorders/citrullinemia; 3. Kidney failure; 4. Pregnancy; 5. Corticosteroids intake in the last 4 weeks; 6. Insulin dependent diabetes mellitus; 7. Celiac disease, Crohn’s disease or other major intestinal malabsorption disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The whole body rate of appearance of glutamine, citrulline and arginine, as well as the conversion of intravenously supplied glutamine into citrulline and arginine at the whole body level. Furtermore, renal turnover of citrulline into arginine in patients receiving L-alanyl-L-glutamine. | — |
Secondary
| Measure | Time frame |
|---|---|
| The quantitative effect of aortic surgery on arginine metabolism in patients treated with or without L-alanyl-L-glutamine. | — |
Contacts
Public ContactP.A.M. Leeuwen, van
P.O. Box 7057
Outcome results
None listed