Patients with end-stage renal disease undergoing a kidney transplantation
Conditions
Interventions
Eligible and consenting patients who will receive a donor kidney will be included for participation in this study. Current practice is to preserve donor kidneys on hypothermic machine perfusion (HMP).
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: • Patients undergoing 1st or 2nd kidney transplant • Patients undergoing a kidney transplantation from DCD Maastricht III & V • Transplant recipients aged = 18 years • Written informed consent
Exclusion criteria
Exclusion criteria: • Patients undergoing 3rd or subsequent kidney transplant • Patients undergoing a kidney transplantation from DCD Maastricht I, II & IV • Transplant recipients aged 12 hrs at the point of arrival at transplant centre • Kidneys with complex vascular anatomy (=3 arteries, artery which cannot be can-nulated or attached to the patch holder) • Kidneys explanted from a donor on normothermic regional perfusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary clinical outcome will be the glomerular filtration rate (GFR) at 6 months post transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary clinical endpoints will include primary non-function, delayed graft function (DGF), patient and graft survival, 7 days and 3 month estimated glomerular filtration rate (eGFR-CKD EPI formula), adverse events and organ discards. Biopsies, samples of perfusate, blood and urine will be collected for biomarker analysis. | — |
Contacts
Public ContactAsel Arykbaeva
Leiden University Medical Center
Outcome results
None listed