1. Central vein catheter
Conditions
Interventions
Urokinase rinses of central vein catheter three times weekly (25,000 IU, 5 ml of 5,000 IU/ml).
Sponsors
Dept of Hematology LUMC
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age of 18 years or older; 2. Admission to undergo intensive cytotoxic treatment associated with disruption of the mucosa and deep granulocytopenia (PMNs < 0.1 x 109/L) for at least 14 days.
Exclusion criteria
Exclusion criteria: 1. Patients with pre-existing bleeding disorders; 2. Patients treated with intravenous unfractionated heparin to prevent veno-occlusive disease; 3. Patients with documented septicaemia prior to the start of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoints of the study were the occurrence of any CVC-related infection by CoNS. According to previously described criteria these infections were classified as local CVC related infection (insertion site infection or significant CVC colonization) and systemic CVC related infections. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints in this study were CVC-related infections caused by other microbial pathogens, premature CVC removal, secondary CVC-related complications (metastatic infection, CVC-related thrombosis), non-CVC related septicaemia bleeding and death. | — |
Contacts
Public ContactM.V. Huisman
Leiden University Medical Center (LUMC) Department of Thrombosis and Haemostasis Room C4-68 P.O Box 9600
Outcome results
None listed