Living kidney donation and the kinetics of proenkephalin.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26466

Enrollment

Registered

2019-12-06

Start date

2019-12-06

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney injury

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - Male or female > 18 years old - Living kidney donor - Baseline kidney function: eGFR > 60 mL/min - Able and willing to provide informed consent

Exclusion criteria

Exclusion criteria: No exclusion criteria

Design outcomes

Primary

Measure	Time frame
•PENK plasma concentration prior to and following kidney donation compared to the kinetics of tubular injury markers •Neutrophil gelatinase-associated lipocalin (NGAL) and TIMP-2*IGFBP7 (Nephrocheck) and functional markers (creatinine and cystatin C plasma concentrations)	—

Secondary

Measure	Time frame
• Association between PENK and estimated GFR (using serum creatinine and cystatin C) following kidney donation • Association between PENK and endogenous creatinine clearance after donating kidney. • Association between peak PENK and creatinine concentrations	—

Contacts

Public ContactRemi Beunders

Radboudumc

remi.beunders@radboudumc.nl0031243665010

Outcome results