high blood pressure, overweight, dietary proteins and carbohydrates hoge bloeddruk, overgewicht, voedingseiwitten en -koolhydraten
Conditions
Interventions
Carbohydrate (maltodextrine) supplementation vs protein (mixture of dietary proteins) supplementation, 10% of total energy intake, isocaloric
Sponsors
NUTRIM
Maastricht University
Maastricht
The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Men and women 2. BMI 25-30 kg/m2 3. High normal or untreated grade 1 hypertension (systolic blood pressure 130-159 mmHg, diastolic blood pressure 85-99 mmHg) 4. Age 20-65 years
Exclusion criteria
Exclusion criteria: 1. Smokers 2. Food allergies 3. Unwillingness to stop use of dietary supplements (except those provided in the study) 4. Use of prescription medication 5. Recent history of or current dieting 6. Gastrointestinal problems 7. Plasma creatinine 7 mmol/L 10. At randomisation: average blood pressure of visits 1 and 2 outside inclusion range for blood pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in office and 24-h ambulatory blood pressure after 4 weeks intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute postprandial effects on cardiac output, renal blood flow, forearm blood flow, endothelial function, sympathetic nervous system activity, renal function, ACE activity Change in acute postprandial effects on cardiac output, renal blood flow, forearm blood flow, endothelial function, sympathetic nervous system activity, renal function, ACE activity after 4 weeks intervention | — |
Contacts
Public ContactM.A. Baak, van
Maastricht University Department of Human Biology P.O. Box 616
Outcome results
None listed