HIV-1 evolution after transmission. A cohort study to identify evolution of recently transmitted HIV-1 infection.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26446

Enrollment

Registered

2009-02-16

Start date

2009-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary HIV-1 infection HIV-1 evolution viral fitness Human Leukocyte antigen (HLA)

Interventions

Venapuncture done twice with 128 ml blood extraction each time.

Eligibility

Inclusion criteria

Inclusion criteria: 1. HIV-1 infected partners who are assumed to be the source of HIV-1 transmission (donor) of patients who present with primary HIV-1 infection at the ‘Primo-SHM’ study (recipient) in the AMC; 2. At least 18 years of age.

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

Measure	Time frame
1. Sequence of the viral genome that is present in the HIV-1 donor as close as possible to the time of HIV-1 transmission; 2. Virus diversity in the donor-recipient pairs half a year after HIV-1 transmission; 3. HLA type of donor-recipient pairs, availability of replication competent (pseudo)viruses from donor and recipient.	—

Secondary

Measure	Time frame
The relation between viral sequence dynamics and: 1. The HLA type of donor and recipient; 2. The autologous neutralization profile; 3. Host CTL responses; 4. Viral fitness.	—

Contacts

Public ContactJ.M. Prins

Academic Medical Center (AMC), Department of Internal Medicine, F4- 217, P.O. Box 22660

j.m.prins@amc.uva.nl+31 (0)20 5664380

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)