The Ehlers-Danlos syndrome is a group of rare genetic disorders caused by a defect in collagen synthesis. Several patients from the EDS patient organisation claimed that for them regional and local anesthesia did not work properly. Up to now there is no proof or explenation for this phenomenon.
Conditions
Interventions
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: For the Ehlers-Danlos group: 1. people with all types of Ehlers-Danlos except type IV, proven by a geneticist or a comparably qualified person; 2. 18 to 65 years old; 3. informed consent. For the control group: All subjects are matched with a patient from the Ehlers-Danlos group for age and sexe.
Exclusion criteria
Exclusion criteria: For Ehlers-Danlos patients: 1. Type IV Ehlers-Danlos; 2. co-existing disease which increases the risk of locoregional anesthesia, according to prudent daily clinical practice; 3. hereditary acquired or drug induced bleeding disorders; 4. periferal mononeuropathy, polyneuropathy, multiple sclerosis or other relevant neurologic disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesia in the region of the ulnar nerve within 60 minutes after application of an ulnar nerve block.This will be demonstrated by increasing stimuli from a neurostimulator. If the subject does not regard 20 mA as painful there is of an adequate block. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Analgesia from the subcutanous injections and the topical application of EMLA cream; 2. Time of onset of analgesia; 3. Time of end of analgesia; 4. Duration of analgesia. | — |
Contacts
Public ContactJ.C. Mier
University Medical Center Utrecht (UMCU), P.O. Box 85500, Heidelberglaan 100
Outcome results
None listed