Primairy prevention of atopic disease by perinatal administration of probiotics.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26444

Enrollment

120

Registered

2005-09-09

Start date

2004-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A randomised double-blind intervention study in pregnant mothers from atopic families and in their newborns.

Interventions

A combination of probiotics (Lact.Lactis, B.Bifidum, B.Infantum), each 1000 milion daily, added to the the formula used.

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant mothers were included if either they themselves or their husband plus a sibling suffered from present or past atopic disease.

Exclusion criteria

Exclusion criteria: 1. Maternal use of immunomodulatory drugs during pregnancy; 2. The use of probiotics.

Design outcomes

Primary

Measure	Time frame
Incidence and severity of atopic disease at the age of 2 years.	—

Secondary

Measure	Time frame
1. SCORAD; 2. Lung function; 3. Serum IgE (Total and specific); 4. Cytokines produced by peripheral blood derived mononuclear cells; 5. Bacterial content of stools during the first weeks of life.	—

Contacts

Public ContactM.O. Hoekstra

University Medical Center Utrecht (UMCU), Wilhelmina Children's Hospital, P.O. Box 85090

m.o.hoekstra@umcutrecht.nl+31 (0)30 2504001

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)