peripheral arterial disease
Conditions
Interventions
Patients randomized to the control group will ondergo a CT scan to determine the coronary calcium score
Patients in the intervention group will undergo a CTscan for calcium score, and a contrast enhanced CT scan for the evalluation of coronary stenosis.
If no stenosis is found a dobutamine stress MRI o
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. PAD patients, stage Fontaine II (intermittent claudication) diagnosed by the vascular surgeon; 2. Patients must provide consent in writing after proper education and discussion with the treating physician and/or research physician; 3. Patients must be aged 50 years or over.
Exclusion criteria
Exclusion criteria: 1. History of symptomatic cardiac disease; 2. Cardiac rhythm other than sinus; 3. Unable to sustain a breath-hold for 25 seconds; 4. Asthma (contraindication beta-blockers); 5. Contra-indications to MRI examination; 6. Contra-indications to iodine contrast; 7. Severe arterial hypertension (>220/120 mmHg); 8. Significant aortic stenosis; 9. Unable to remain in supine position for at least 60 minutes; 10. Morbidly obese (BMI > 40); 11. Renal insufficiency (creatinine >140mmol/l); 12. Severe physical deterioration due to concomitant illness; 13. Language barrier; 14. Acute coronary syndrome. 15. Contra-indications to dobutamine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatal and non-fatal myocardial infarction and stroke, and vascular death (death due to vascular disease). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Fatal and non-fatal myocardial infarction; 2. Fatal and non-fatal stroke; 3. Vascular interventions; 4. Amputation; 5. Aortic rupture; 6. End stage renal failure; 7. Extra cranial hemorrhage; 8. Complications of CABG or PTCA; 9. All cause mortality. | — |
Contacts
Public ContactA.M. Vos, de
University Medical Center Utrecht (UMCU), Housepost nr E.01.132, P.O. Box 85500
Outcome results
None listed