Lipid-induced insulin resistance.

Lipid-induced insulin resistance in Endurance-trained and untrained men.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26429

Enrollment

Registered

2009-09-10

Start date

2006-02-08

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mitochondrial function, insulin resistance mitochondrieel functioneren, insuline resistentie

Interventions

All subjects will undergo three hyperinsulinemic euglycemic clamps, in a random order, with simultaneous infusion of either glycerol (control trial), LCT or MCT/LCT.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male sex; 2. Age 18-35 years; 3. BMI < 25 kg/m2; 4. Stable dietary habits.

Exclusion criteria

Exclusion criteria: 1. Family history of diabetes; 2. Medication use.

Design outcomes

Primary

Measure	Time frame
Insulin sensitivity (hyperinsulinemic-euglycemic clamp) and mitochondrial function.	—

Secondary

Measure	Time frame
1. Whole body oxidative capacity; 2. Body composition; 3. Skeletal muscle mitochondrial markers; 4. Muscle lipid accumulation; 5. Expression of proteins involved in fatty acid handling; 6. Insulin signalling in skeletal muscle.	—

Contacts

Public ContactPatrick Schrauwen

Postbus 616 Department of Human Biology Maastricht University Medical Center

p.schrauwen@hb.unimaas.nl+31(0)43-388 15 02

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)