Ketoacids during hemodialysis

Ketoacid ingestion along with protein to attenuate muscle catabolism during hemodialysis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26423

Enrollment

Registered

2021-02-26

Start date

2021-03-22

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End-stage renal disease

Interventions

During two HD sessions, included patients will ingest sips of (1) a protein beverage and (2) a protein and ketoacid beverage. Throughout the HD session, arterial and venous plasma samples and breath s

Eligibility

Inclusion criteria

Inclusion criteria: - Aged >18 years - Ability to provide written informed consent - Hemodialysis treatment for >3 months - Well-functioning arteriovenous shunt in upper or lower arm

Exclusion criteria

Exclusion criteria: - Hospitalization 200/100mm Hg) or arrhythmia - Previous episodes of intradialytic hypotension related to food intake - Allergies to milk proteins - Dysphagia - Pregnancy - Cognitive disorders

Design outcomes

Primary

Measure	Time frame
The primary endpoint in this study will be the net AA balance over the forearm, calculated by subtracting the venous from arterial AA concentrations.	—

Secondary

Measure	Time frame
Secondary study parameters include plasma and breath L-(ring-13C6)-phenylalanine enrichments and AA concentrations in spent dialysate.	—

Contacts

Public ContactFloris Hendriks

Maastricht University Medical Centre+ / NUTRIM School of Nutrition and Translational Research in Metabolism / Department of Human Biology

f.hendriks@maastrichtuniversity.nl0655522347

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)