Endometriosis, Retrograde menstruation, theory of Sampson.
Conditions
Interventions
On Cycleday 2 and Cycleday 20 a gynaecological investigation, a transvaginal ultrasound and MRI will be performed. Also a bloodsample (serum Ca 125) will be collected.
In case of a cystectomy also a p
Sponsors
VU University Medical Center, Department of Obstetrics and Gynaecology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Female<40 years; 2. Subfertility; 3. Patent tubes (at HSG or laparoscopy with chromopertubation); 4. Regular menstrual cycle (28 days +/- 3 days); 5. Cases: presence of endometriosis confirmed by laparoscopy; 6. Controls: no presence of endometriosis confirmed by laparoscopy; 7. Signed informed consent; 8. Negative pregnancy test.
Exclusion criteria
Exclusion criteria: 1. Female age>40 years; 2. Hormone therapy; 3. Contra indications for MR imaging (e.g.pacemaker, claustrophobia); 4. Positive pregnancy test; 5. Laparoscopy > 1 year ago; 6. Evidence of tubal occlusion seen at HSG or laparoscopy; 7. Presence of any malignancy; 8. Frozen pelvis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in the amount of blood-stained peritoneal fluid measured by TVUS and MRI in women with endometriosis versus healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The localisation and amount of resorption of blood stained peritoneal fluid; 2. The volume and aspect of endometrial cysts; 3. Signal intesity and thickness of the junctional zone in endometriosis patients and controls; 4. Apperent Diffusion coefficient (ADC) in endometrial cysts, myometrium and junctional zone. | — |
Contacts
Public ContactA.B. Luchinger
De Boelelaan 1117, PK 6 Z 180
Outcome results
None listed