Natural Killer cell phenotype in unexplained recurrent miscarriages

The role of Natural Killer cells in unexplained recurrent miscarriages

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26396

Enrollment

126

Registered

2020-01-15

Start date

2019-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unexplained recurrent miscarriages

Interventions

None

Eligibility

Inclusion criteria

Inclusion criteria: Group 1: Recurrent (>2) unexplained miscarriages, defined by normal parental karyotype, no maternal thrombophilia and no uterine abnormality Group 2: Previous uncomplicated pregnancy, defined by healthy live birth after 37 weeks of gestation without major obstetric complications

Exclusion criteria

Exclusion criteria: - Current or recent (<3 months ago) pregnancy - Current or recent (<2 weeks) symptomatic genital infection such as chlamydia, gonorrea or pelvic inflammatory disease. - Younger than 18 or older than 36 years - Unable to give consent in Dutch

Design outcomes

Primary

Measure	Time frame
Percentage of NK cells with an activating phenotype in peripheral blood	—

Secondary

Measure	Time frame
- Percentage of NK cells with an activating phenotype in menstrual blood - VO2 max: measured in millilitres per kilogramme of body weight per minute - Lifestyle questionnaire: Simple Lifestyle Indicator Questionnaire (SLIQ) score - Total body water: fat free mass in kilogramme of body weight	—

Contacts

Public ContactDenise Habets

Maastricht UMC+

denise.habets@mumc.nl0031433874152

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)