APATHY AND ACTIGRAPHY

ACTIGRAPHY AS A NEW OBJECTIVE MEASURE FOR APATHY IN SCHIZOPHRENIA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26377

Enrollment

Registered

2017-07-11

Start date

2017-07-15

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

apathy, schizophrenia, negative symptoms

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Participants in the schizophrenia reference group should be at least 18 years of age. Sex, age, medication use, season of actigraphy measurement and education will be matched to the schizophrenia patients scoring high on apathy recruited in the Apathy study (Randomized controlled trial of neurostimulation treatment for apathy in schizophrenia, METC2013.137). Patients Participants are included if they score below 27 on the Apathy subscale of the AES-C. The Mini International Neuropsychiatry Interview- plus (MINI-plus) will be used to confirm the diagnosis of schizophrenia or schizoaffective disorder. At least four weeks prior to the start of the treatment the pharmacological treatment should be stable. ParticipantsThe patients should remain on their regular medication for the complete duration of the study. Furthermore, participants should have a normal level of exercise tolerance and no physical handicaps that limit their radius of action. Moreover, participants should have weekends, wherein they are free from work (i.e. do not have to work weekend shifts) Participants in the healthy reference group should be at least 18 years of age. Sex, age, season of actigraphy measurement and education will be matched to the schizophrenia patients scoring high on apathy recruited in the Apathy study (Randomized controlled trial of neurostimulation treatment for apathy in schizophrenia, METC2013.137). Healthy controls are included if they score below 27 on the Apathy subscale of the AES-S. Furthermore, participants should have a normal level of exercise tolerance and no physical handicaps that limit their radius of action. Moreover, participants should have weekends, wherein they are free from work (i.e. do not have to work weekend shifts)

Exclusion criteria

Exclusion criteria: Exclusion criteria for the schizophrenia reference group: • An apathy score above 27 on the apathy subscale of the AES-C • Current disorder of substance abuse (excluding nicotine addiction) • Insufficient Dutch language abilities Exclusion criteria for the healthy reference group: • History of or current psychiatric or neurological illness, based on the report of the subject whether he/she had contact with psychiatrist/neurologist in the past. • An apathy score above 27 on the apathy subscale of the AES-S • Insufficient Dutch language abilities

Design outcomes

Primary

Measure	Time frame
First, descriptives are calculated on (e.g. mean, median, maximum, minimum, standard deviation) and plotted for (e.g. histograms and normality plots) abovementioned motor behavior measures. Second, aA factorial ANCOVA is applied performed to investigate differences in the quantity, variability, and initiation of motor behavior between patients with schizophrenia that score high on apathy, patients with schizophrenia that score low/average on apathy and healthy controls, while controlling for age, BMI, illness duration, medication, and depression. Furthermore, a backward stepwise multiple regression is applied to investigate the predictive value of the quantity, variability, and initation of motor behavior for apathy severity. The motor behavior measures are entered separately into the stepwise multiple regression (backward) models as dependent variables and the apathy symptom measure AES-C is entered as a predictor. In a subsequent step, age, Body Mass Index (BMI), illness duration, medication use and depression are entered into the three separate regression models to evaluate if variations in motor behavior could be explained by these variables (Kos et al., submitted). If necessary, we will correct for multiple testing using the SISA Bonferroni correction.	—

Measure

Time frame

First, descriptives are calculated on (e.g. mean, median, maximum, minimum, standard deviation) and plotted for (e.g. histograms and normality plots) abovementioned motor behavior measures. Second, aA factorial ANCOVA is applied performed to investigate differences in the quantity, variability, and initiation of motor behavior between patients with schizophrenia that score high on apathy, patients with schizophrenia that score low/average on apathy and healthy controls, while controlling for age, BMI, illness duration, medication, and depression. Furthermore, a backward stepwise multiple regression is applied to investigate the predictive value of the quantity, variability, and initation of motor behavior for apathy severity. The motor behavior measures are entered separately into the stepwise multiple regression (backward) models as dependent variables and the apathy symptom measure AES-C is entered as a predictor. In a subsequent step, age, Body Mass Index (BMI), illness duration, medication use and depression are entered into the three separate regression models to evaluate if variations in motor behavior could be explained by these variables (Kos et al., submitted). If necessary, we will correct for multiple testing using the SISA Bonferroni correction.

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Contacts

Public Contactm.n. servaas

m.n.servaas@umcg.nl

Outcome results