Prediction of radiation induced lung damage based on dose distribution and tumour location.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26373

Enrollment

Registered

2009-07-10

Start date

2009-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radiotherapy is based on reaching the equilibrium between optimal tumor control and an acceptable chance of radiation induced side effects. In case of lung cancer, the prediction of radiation induced lung damage based on physical dose volume-parameters is limited. Thus, some patients may be undertreated, receiving lower doses than that they may safely tolerate. This study aims to investigate the relationship between dose-distribution and tumor location on the development of radiation induced c

Interventions

Research CT-scans are performed prior to and 6, 24, 52 weeks after completion of treatment. This time course covers acute radiation pneumonitis (6-26 weeks after treatment) and the development of radi

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age > 18 years; 2. WHO PS 0-2; 3. Stage IIIA/IIIB Non Small Cell Lung Cancer (NSCLC); 4. Limited disease Small Cell Lung Cancer; 5. Adequate pulmonary lung function; 6. Life expectancy of at least 6 months.

Exclusion criteria

Exclusion criteria: 1. WHO PS=3; 2. Life expectancy < 6months.

Design outcomes

Primary

Measure	Time frame
Density changes measured with serial CT-scans scored using the newly developed quantification method.	—

Secondary

Measure	Time frame
1. The regional dependency of structural lung damage (tumor location); 2. The relationship between lung density changes and dose distribution; 3. The dynamics of structural lung damage (density changes) in time.	—

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)