Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Before and after rehabilitation, microvascular changes and reactivity will be measured using retinal imaging and endothelial function will be analyzed via reactive hyperemia, blood pressure and ankle
Sponsors
VITO and CIRO
Eligibility
Inclusion criteria
Inclusion criteria: -COPD as a primary diagnosis according to the Global Initiative For Chronic Obstructive Lung Disease (GOLD) definition: ”Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. Its pulmonary component is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases”. COPD is diagnosed by a chest physician. -Clinically stable on the basis of clinical picture by chest physician. -Treated according to the current international guidelines. -Permission for voluntary participation. Patients will be asked during baseline assessment and have to sign an informed consent. Patients have the right to withdraw from the study without any negative consequences on their rehabilitation. -Attending the regular rehabilitation program in Ciro+
Exclusion criteria
Exclusion criteria: -Lack of motivation for voluntary participation in this study. -The presence of abnormalities in the lens (e.g. cataract) or retina (e.g. retinal detachment), which makes it impossible to make an image of the retina. -The presence of severe diabetic retinopathy, which makes it impossible to analyze the microvasculature of the retina.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence of changes in the retinal microvasculature (for example change in vessel caliber, geometric pattern, etc) in patients with COPD. | — |
Secondary
| Measure | Time frame |
|---|---|
| -Endothelial function analyzed via reactive hyperemia, blood pressure and ankle brachial index in patients with COPD. -The effect of a high-intensity exercise on the reactivity of the retinal microvasculature in patients with COPD compared to non-COPD subjects (obtained in an earlier study). -The effect of an 8-week inpatient rehabilitation program on the retinal vessel calibers in patients with COPD. -The association between 1) retinal vessel changes/retinal vascular reactivity and cardiovascular phenotyping (endothelial function, blood pressure, ankle brachial index, AFR), 2) retinal vessel changes/retinal vascular reactivity and relevant outcomes for COPD patients (e.g. lung function, CAT, 6MWT, CPET, CWRT, smoking status; all included in the routine baseline assessment prior to rehabilitation) | — |
Contacts
Public ContactAnouk Vaes
CIRO, expertise centre for chronic organ failure
Outcome results
None listed