subject with suspected Deep Venous Thrombosis (DVT)
Conditions
Interventions
Acenocoumarol in subjects with proven DVT according to current guidelines.
Sponsors
AMC-UvA
Eligibility
Inclusion criteria
Inclusion criteria: 1. Males or postmenopausal females; 2. Age between 18 and 60 years; 3. Suspicion of DVT at time of inclusion; 4. Written informed consent for future evaluation at time of diagnosis; 5. Fasted (no meal, coffee or tea) for at least 3 hours.
Exclusion criteria
Exclusion criteria: 1. Smoking > 5 sig/day; 2. Premenopauzal females (due to hormonal changes); 3. Patients any medication including oral antionceptives and PPIs; 4. Use of antibiotics in last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in fecal flora/gutmicrobiota (HITCHIP see Qin Nature 2010) analysis of 1200 known intestinal bacteria in subjects with DVT vs subjects with a clinical suspicion of DVT but the absence of this diagnosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Associations between gutmicrobiota changes (HITCHIP), plasma levels of coagulation (Endogenous thrombin potential) and endothelial gycocalyx metabolism (SDF sublingual imaging and plasma hyaluronan and heparansulphate by ELISA). | — |
Contacts
Public ContactM. Nieuwdorp
AFDELING INWENDIGE GENEESKUNDE AMC MEIBERGDREEF 9, KAMER F4.159.2
Outcome results
None listed