OPMs for epilepsy

Wearable MEG - Using novel technology to improve surgery outcome in epilepsy patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26326

Enrollment

Registered

2020-09-22

Start date

2020-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - Patients have refractory epilepsy (not responding to treatment with anti-epileptic drugs) and are candidates for epilepsy surgery at VUmc (adults) or UMCU (children). - We include adults (VUmc) or children of six years of age or older (UMCU). Adults: - Patients have already undergone a clinical SQUID-based MEG and dEEG at VUmc - 3 patients: confirmed focal source on dEEG of mesial temporal origin - 1 patient: frequent seizures (~daily) Children: - Six years of age or older - Patients have already undergone a clinical SQUID-based MEG with simultaneous scalp-EEG at VUmc - Confirmed focal source of epileptiform activity in clinical MEG or EEG

Exclusion criteria

Exclusion criteria: - Already undergone surgery for their current epilepsy - The patients have already undergone a clinical SQUID-based MEG. Those patients who had claustrophobic or anxiety experiences from being enclosed in the magnetically shielded room will be excluded - Patients with many artefacts, related to either movement (restlessness, i.e. not seizure-related) or metal implants (not MEG compatible), on their clinical SQUIDbased MEG

Design outcomes

Primary

Measure	Time frame
Primary outcome is a demonstration of the effectiveness of OPMs as a powerful diagnostic tool in epilepsy. The parameter we study is epileptiform activity (spikes, spike-waves). We will compare the even-rate (number of spikes/minute) and the strength (in terms of signal-to-noise ratio) between the different techniques (OPM-based MEG versus SQUID-based MEG, and scalp EEG or dEEG). OPM-based MEG will be considered more effective if the event-rate or strength is higher than for the SQUID-based MEG.	—

Measure

Time frame

Primary outcome is a demonstration of the effectiveness of OPMs as a powerful diagnostic tool in epilepsy. The parameter we study is epileptiform activity (spikes, spike-waves). We will compare the even-rate (number of spikes/minute) and the strength (in terms of signal-to-noise ratio) between the different techniques (OPM-based MEG versus SQUID-based MEG, and scalp EEG or dEEG). OPM-based MEG will be considered more effective if the event-rate or strength is higher than for the SQUID-based MEG.

—

Secondary

Measure	Time frame
Demonstration of the ability to successfully record MEG signals during a seizure, i.e. to be able to identify epileptiform activity in a MEG signal that is not saturated by movement-artefacts.	—

Contacts

Public ContactArjan Hillebrand

Amsterdam UMC, Location VUmc

a.hillebrand@amsterdamumc.nl+31 (20)4440723

Outcome results