Heroine dependence Cocaine dependence drug addiction
Conditions
Interventions
Treatment by means of deep brain stimulation of the nucleus accumbens area. Deep brain stimulation (DBS) is a neurosurgical intervention in which implanted electrodes deliver electrical pulses to ster
Sponsors
Academic Medical Center Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Minimal duration of 5 years of the DSM-IV diagnosis heroin and/or cocaine dependence; 2. Treatment refractory on other evidence based interventions; 3. Severity of the current dependence diagnosis is indicated by: A. Heroin and or cocaine use at least 15 days in the last month; AND; B. Poor physical health (MAP-HSS > 8); AND/OR; C. Poor mental health (SCL-90 > 41 (male) or > 60 (female); AND/OR; D. Poor social function with at least six days of illegal activities in the previous month and/or at least six days in the previous month without personal contact with a non-drug-using person.
Exclusion criteria
Exclusion criteria: 1. Current suicidality; 2. Current psychosis and no history of psychosis; 3. (History of) severe neurological disorders, e.g. Parkinson's disease, CVA, dementia; 4. Contraindication to perform the operation; 5. Contraindication to participate in fMRI and/or SPECT assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Drug use: gr/day by interview and urine testing; 2. Drug craving: DDQ, OCDUS; 3. Neuropsychological functioning: CANTAB; 4. Changes brain activation: fMRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in eating and sexual activity: interview; 2. Depression: Hamilton depression scale; 3. OCD symptoms: Y-BOCS; 4. Smoking: FTND. | — |
Contacts
Public ContactJudy Luigjes
Department of Psychiatry Academic Medical Center University of Amsterdam Meibergdreef 5
Outcome results
None listed